For further information about unapproved drugs, click here. Phenobarbital Sodium Injection Description The barbiturates are nonselective central nervous system CNS depressants which are primarily used as sedative hypnotics and also anticonvulsants in subhypnotic doses.
An induced coma can also be known as a barbiturate-induced coma, or barb coma. Some also call it an artificial coma. As the name suggests, this type of coma is totally different from a real or natural coma in the sense that this is medically induced.
Doctors make a patient to temporarily lose their consciousness by the use of a barbiturate drug. Almost all medically induced comas are made possible by the use of the drugs pentobarbital and thiopental. These drugs are very powerful barbiturate drugs.
What is the essence of a medically induced coma?
Medically induced coma is normally performed on patients who are suffering from a brain injury. The major reason why coma is induced medically is in order to protect the brain from any brain damage after a major head injury or a grave medical condition. What the barbiturate drugs do is that they narrow the blood vessels in the brain and reduce the blood flow there so that there is less pressure on it.
When a person has an accident and severely injures his head, the brain gets injured and this leads to fluids accumulating rapidly in the brain. The accumulation of fluids in the brain will cause the brain to enlarge or swell. Since the skull is hard, it does not allow the brain to expand and therefore forces it to compress.
As a result of this, there is massive pressure on the brain. This pressure is extremely dangerous for the health of the patient because it can prevent blood carrying oxygen from reaching all parts of the brain, which can lead to permanent brain damage.
The pressure can also force the delicate tissue of the brain to push violently against the hard parts of the skull. This can cause the brain tissue to get damaged and die. This can lead to the death of the patient.
It is in order to prevent the above from happening that a medically induced coma is important. The barbiturate drugs given to the patient will send the patient into a coma and reduce the pressure on the brain. It will prevent the brain from swelling. With the decrease in pressure in the brain and swelling of the brain, brain damage can be stopped.
While many studies have shown that barbiturate-induced coma is very important when it comes to reducing intracranial hypertension or pressure, a few studies have suggested that barbiturate-induced coma might not be totally capable of preventing damage to the brain because although it helps in reducing intracranial hypertension, it is only temporary.
What is a Medically Induced Coma and Why is it used?The value of these ancillary measures is supported for the most part by clinical impressions of shortened duration of coma and by reduced blood levels of drug. Induced diuresis has recently received much attention, but data demonstrating increased clearances of .
There was a trend towards better outcome for patients with normal temperature than those with hyper- or hypothermia (favorable outcome 64% versus 29 and 33% respectively).[timberdesignmag.com] We report the use of intracranial pressure monitoring, mild hypothermia and barbiturate coma in a patient with meningococcal meningitis complicated by raised intracranial pressure.
Frawley et al. also indicated in a study of 37 carotid endarterectomies that barbiturate-induced cerebral protection may prevent ischemic stroke due to intraoperative cross-clamping and plaque migration, and may also be preferred to intraluminal shunting due to the inherent risks involved in shunting.
Experimental Study on the Indications for Barbiturate Therapy Change in Haemodynamics and the Influence of Dopamine tion increased till the barbiturate-induced coma stage. Furthermore, Experimental Study on the Indications for Barbiturate Therapy.
M. Sato et al. Read "Barbiturate coma for severe, refractory vasospasm following subarachnoid haemorrhage, Intensive Care Medicine" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Jan 14, · Determine if the barbiturate overdose represents a suicide attempt. Do not overlook the patient's medical history. Most notably, a history of liver disease could potentially result in .